Lab News & Events
Going Viral
From therapeutics to gene transfer, bacteriophages offer a sustainable and powerful method of controlling microbes.
The Line Islands Collection
In the run-up to an upcoming expedition to the Southern Line Islands in fall of 2013, a collection of related articles has been launched in the open access journal PeerJ. Two of the manuscripts presented in this paper collection show the use oxygen optodes to visualize micro-scale oxygen gradients at coral-algal interfaces and for biological oxygen demand.
Another study investigates how different functional groups of benthic primary producers, like corals, calcifying-, macro- and turf- algae "culture" up different microbes and thereby alter the microbial community metabolism.
This series of studies was driven by the demand to better understand the mechanisms underlying the alterations in coral reef community compositions as a result of human disturbance. The focus hereby lies on interaction processes between the microbial community and macro-organisms, like fish, coral, or algae, and on the reciprocal effects of both micro- and macro- organisms on key water parameters like oxygen, carbon, or nutrient concentrations.
The joint efforts of different laboratories specialized in multiple scientific disciplines allow for a more facetted view on the task of detecting overarching mechanisms which shape the structure of these different communities. Thanks to the opportunity provided by the newly established open-access online journal PeerJ, we can present these studies together in one confluent paper collection (https://peerj.com/collections/1-line-islands/) and will add further studies to the Collection arising from our continuing efforts. This new concept will enable other researchers to better conceptualize these and future findings in their broader context.
BAM interview on FOX5 San Diego
Watch the BAM interview on FOX5 San Diego news:
- SDSU team discovers why we need mucus, FOX5 News
Jeremy Barr interview KFWB-L.A. radio interview
Watch the BAM interview on FOX5 San Diego news:
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Listen to Jeremy Barr's interview on KFWB-L.A. radio
Jeremy Barr Reddit AMA
Checkout Jeremy 's AMA on Reddit
BAM in the news
More stories about BAM in the news:
- Stuck in Phage Heaven, ASM Small Things Considered
- Mucus found to harbor a previously unknown human immune system, Gizmag
- New Immune System Discovered, ZeitNews
BAM in the news
BAM stories in the news:
- A virus shield, The Economist
- Story behind the paper: from Jeremy Barr on "Bacteriophage and mucus. Two unlikely entities, or an exceptional symbiosis? ", The Tree of Life
- Podcast: Friendly Viruses, Weaning Neandertals, and Why Penguins Don't Fly, Science (Podcast)
- Viruses in our mucus protect against infections, BioSpectrum
- "Friendly Viruses" Shield Us From Infection, Medical News Today
BAM in the news
A few more stories about BAM in the news:
- Story behind the paper: from Jeremy Barr on "Bacteriophage and mucus. Two unlikely entities, or an exceptional symbiosis? ", The Tree of Life
- "Friendly Viruses" Shield Us From Infection, Medical News Today
- New immune system discovered, Medical Express
- Viruses in our mucus protect against infections, BioSpectrum
- The Good Virus, BioTechniques
- New health benefits can come from mucus and viruses, researchers find., Medill Reports Chicago, Northwestern University.
Bacteriophage adhering to mucus provide a non-host-derived immunity
The protective layer of mucus on the body's surface serves both as an entry point for pathogens and a home for large populations of beneficial microbes. This mucus layer harbors a large diversity of both bacteria and phage. We show elevated concentrations of phage on all mucosal surfaces sampled, ranging from cnidarians to humans, compared to the surrounding environment.
Using bacteriophage T4 and various in vitro tissue culture cells as a model system, Jeremy J. Barr et. al. demonstrate that this increase in phage abundance is mucus-dependent. This phage-mucus association reduces bacterial attachment and colonization of the mucus, which subsequently protects the underlying epithelium from bacterial infection. Enrichment of phage in mucus occurs via binding interactions between variable glycan residues displayed in mucus and immunoglobulin-like protein domains exposed on phage capsids.
Based on these observations we propose the Bacteriophage Adherence to Mucus (BAM) model that provides a ubiquitous, but non-host-derived, immunity applicable to mucosal surfaces. This benefits the metazoan host by limiting mucosal bacteria, and benefits the phage through more frequent interactions with bacterial hosts. BAM suggests the first demonstration of a symbiotic interaction between phage and metazoan hosts that provides a previously unrecognized immunity that actively protects mucosal surfaces.
Read the full article at PNAS: Barr et al. "Bacteriophage adhering to mucus provide a non–host-derived immunity"
BAM in the news
Several stories have been published in the media about the BAM paper. Here are a few:
- Meet Your New Symbionts: Trillions of Viruses, National Geographic
- Viruses in the gut protect from infection, Nature
- Protective Phages, TheScientist
- Friendly Viruses Protect Us Against Bacteria, Science
- Viruses and mucus team up to ward off bacteria, ScienceNews